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  • Title: [Clinical control, study of viral shedding and evaluation of circulating and local antibody response after administration of live and attenuated "Alice" strain influenza vaccine].
    Author: Bergamini F, Profeta ML, Ferroni P, Zanetti AR.
    Journal: Boll Ist Sieroter Milan; 1976 Mar; 55(71):1-12. PubMed ID: 1021151.
    Abstract:
    Thirty-four young adults were inoculated intranasally by nose drops with two doses, two weeks apart, of inhibitor resistant "Alice" vaccine strain of A/England/42/72 (H3N2). By the rate of volunteers with clinical reactions, always mild and short-lasting, the vaccine showed a low degree of reactogenicity. Viral shedding was evidenced only the day after the first dose and was limited to two vaccinees. Two weeks after the first dose homologous serum h.i.a. appeared in all the 15 volunteers lacking prevaccination antibody and significant titer rises occurred in a substantial number of vaccine recipients with low titers. The incidence of subjects with h.i.a at titers considered to be protective (larger than or equal to 1:40), which was 26% before vaccination, rose to 93% in fully vaccinated volunteers. Very likely because of the presence of n.i.a. in the prevaccinal serum of all the volunteers, the n.i.a. response was less satisfactory. The vaccine induced h.i.a. to A/Port Chalmers/73 e A Scotland/74 (H3N2) variants, although in a lower titer than to the homologous strain. Serum h.i. and n.i. antibody response appeared not to be significantly increased by a second dose. H.i.a., never present in the first sample, were found in the nasal washings taken two weeks after the second dose from 9 out of 16 vaccinees examined. Antibody was detected more frequently in the specimens with relatively high levels of protein and IgA. Secretory n.i.a., already demonstrable in 7 volunteers before vaccination, were acquired by all but one at the end of the experience.
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