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  • Title: OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects) in monozygotic twins.
    Author: Lee DH, Cottrell JR, Sanders RC, Meyers CM, Wulfsberg EA, Sun CC.
    Journal: Am J Med Genet; 1999 May 07; 84(1):29-33. PubMed ID: 10213043.
    Abstract:
    The omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a consistent and recognizable pattern of midline abdominal and pelvic defects. It is rare, affecting 1 in 200,000 to 400,000 pregnancies and is even rarer in twin gestations. This is an autopsy study of OEIS complex in monozygotic twins after pregnancy termination at 20 weeks of gestation. Unremarkable family history but concordance of monozygotic twins for the defects may support the theory that early malformation complexes, e.g., OEIS, and monozygotic twinning are manifestations of the same disturbance of early blastogenesis.
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