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  • Title: The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b.
    Author: Rice GP, Paszner B, Oger J, Lesaux J, Paty D, Ebers G.
    Journal: Neurology; 1999 Apr 12; 52(6):1277-9. PubMed ID: 10214759.
    Abstract:
    The fate of the neutralizing antibody (NAB) in MS patients treated with interferons remains unclear. We conducted a follow-up survey of NAB titers in 59 long-term treated patients from the London and Vancouver cohorts of the pivotal trial of interferon alpha-1b. NAB were measured with the myxovirus protein A assay and an ELISA, at a mean follow-up that exceeded 8 years. NAB disappeared in the majority of patients.
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