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  • Title: Quantitative study of germinal center area in normal and diseased tonsils using image analysis.
    Author: Gorfien JL, Hard R, Noble B, Brodsky L.
    Journal: Ann Otol Rhinol Laryngol; 1999 Apr; 108(4):398-402. PubMed ID: 10214789.
    Abstract:
    The aim of this study was to measure the germinal center area of secondary follicles in a consistent and unbiased manner using image analysis. Tonsil specimens were obtained from children with clinical evidence of recurrent tonsillitis and/or idiopathic tonsillar hypertrophy. Normal control biopsy specimens were obtained from children with no history of ear, nose, or throat infections. The results show a significant increase in the germinal center area in tonsils exhibiting hypertrophy when compared to normal controls (p < .002). Image analysis is an important tool for making quantitative size comparisons in lymphoid tissues.
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