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  • Title: Quantitative analysis of interleukin 6 (IL-6) in patients with IgA nephropathy after tonsillectomy.
    Author: Baba Y, Akagi H, Fukushima K, Kosaka M, Hattori K, Nishizaki K, Ogawa T, Masuda Y, Shikata K.
    Journal: Auris Nasus Larynx; 1999 Apr; 26(2):177-82. PubMed ID: 10214897.
    Abstract:
    The biological response to tonsillectomy was studied in 21 patients suffering from chronic tonsillitis with or without IgA nephropathy (IgAN). Serum and urinary interleukin-6 (IL-6) levels were measured before and after tonsillectomy. Serum IL-6 levels in case of IgAN peaked 3 h after tonsillectomy and more rapidly than control cases. No significant differences were observed between two cases through the time. Urinary IL-6 levels were significantly higher before and at 6 and 48 h after tonsillectomy in IgAN cases. Stimulation of tonsils caused serum IL-6 elevation and changes in urinary IL-6 levels in IgAN cases. Elevation of urinary IL-6 levels after tonsillectomy in patients with IgAN may reflect an increase in the production of IL-6 in the kidneys. Measurement of urinary IL-6 levels after tonsillectomy is useful to elucidate the efficacy of tonsillectomy in IgAN patients.
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