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  • Title: DNA triple helix stabilisation by a naphthylquinoline dimer.
    Author: Keppler M, Zegrocka O, Strekowski L, Fox KR.
    Journal: FEBS Lett; 1999 Mar 26; 447(2-3):223-6. PubMed ID: 10214950.
    Abstract:
    We have used DNase I footprinting to examine the effect of a novel naphthylquinoline dimer, designed as a triplex-specific bis-intercalator, on the stability of intermolecular DNA triplexes. We find that this compound efficiently promotes triplex formation between the 9-mer oligonucleotide 5'-TTTTTTCTT and its oligopurine duplex target at concentrations as low as 0.1 microM, enhancing the triplex stability by at least 1000-fold. This compound, which is the first reported example of a triplex bis-intercalator, is about 30 times more potent than the simple monofunctional ligand.
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