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  • Title: Anandamide activates human platelets through a pathway independent of the arachidonate cascade.
    Author: Maccarrone M, Bari M, Menichelli A, Del Principe D, Agrò AF.
    Journal: FEBS Lett; 1999 Mar 26; 447(2-3):277-82. PubMed ID: 10214961.
    Abstract:
    Anandamide (arachidonoylethanolamide, AnNH) is shown to activate human platelets, a process which was not inhibited by acetylsalicylic acid (aspirin). Unlike AnNH, hydroperoxides generated thereof by lipoxygenase activity, and the congener (13-hydroxy)linoleoylethanolamide, were unable to activate platelets, though they counteracted AnNH-mediated stimulation. On the other hand, palmitoylethanolamide neither activated human platelets nor blocked the AnNH effects. AnNH inactivation by human platelets was afforded by a high-affinity transporter, which was activated by nitric oxide-donors up to 225% of the control. The internalized AnNH could thus be hydrolyzed by a fatty acid amide hydrolase (FAAH), characterized here for the first time.
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