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  • Title: Effect of strontium on the epiphyseal cartilage plate of rat tibiae-histological and radiographic studies.
    Author: Matsumoto A.
    Journal: Jpn J Pharmacol; 1976 Dec; 26(6):675-81. PubMed ID: 1021603.
    Abstract:
    Following dietary administration of strontium carbonate, histological and radiographic changes in the epiphyseal cartilage plate of the rat tibiae were examined in the present study. The weight gain of the rat fed a strontium diet was less than that of the control rats. Longitudinal growth of tibiae and endochondral ossification were inhibited by strontium administration. The widths of both proximal and distal cartilage plates increased enormously as has also been shown by other investigators. Sizes of chondroblasts in columns of proximal cartilage plate in rats fed a strontium diet were smaller than those of the control rats and were not different between upper and lower parts. It is suggested that strontium inhibits bone growth through the inhibitory action on the maturation process of chondroblasts and the succeeding endochondral ossification.
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