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  • Title: Cotinine replacement levels for a 21 mg/day transdermal nicotine patch in an outpatient treatment setting.
    Author: Gariti P, Alterman AI, Barber W, Bedi N, Luck G, Cnaan A.
    Journal: Drug Alcohol Depend; 1999 Apr 01; 54(2):111-6. PubMed ID: 10217550.
    Abstract:
    This study examined plasma cotinine replacement levels of 56 outpatient smokers administered a 21 mg/day transdermal nicotine patch (Nicoderm CQ ). The percentage of cotinine replacement ranged from 35 to 232% (mean 107%; median 90.5%). Four subject variables were found to be significantly correlated with percentage of cotinine replacement-baseline cotinine level, prior quit attempts, gender, and the Fagerström Tolerance Questionnaire score. A two-variable model consisting of baseline cotinine level and gender provided the most powerful predictor combination. The percentage of cotinine replacement was not predictive of post-treatment smoking. The relatively high levels of cotinine replacement obtained using the Nicoderm CQ 21 mg/day patch suggest cautious use of higher dose treatment with this particular patch.
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