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  • Title: Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii.
    Author: Hwang BY, Kim SE, Kim YH, Kim HS, Hong YS, Ro JS, Lee KS, Lee JJ.
    Journal: J Nat Prod; 1999 Apr; 62(4):640-3. PubMed ID: 10217732.
    Abstract:
    The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl- (1-->4)-b eta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 microM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.
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