These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues.
    Author: Anning PB, Chen Y, Lamb NJ, Mumby S, Quinlan GJ, Evans TW, Gutteridge JM.
    Journal: FEBS Lett; 1999 Mar 19; 447(1):111-4. PubMed ID: 10218593.
    Abstract:
    Haem oxygenase-1 is upregulated by numerous insults, including oxidative stress, and under such circumstances it is considered to be a protective stratagem. We have measured the haem oxygenase-1 expression in heart, lung and liver tissues of control and iron-overloaded rats. Lung tissue from iron-overloaded rats displayed a significant increase in the haem oxygenase-1 protein but no changes in haem oxygenase-1 mRNA. Conversely, heart tissue showed a significant increase in haem oxygenase-1 mRNA but no changes in haem oxygenase-1 protein. We conclude that during oxidative stress caused by iron overload, lung tissue responds with a rapid upregulation of haem oxygenase-1 levels.
    [Abstract] [Full Text] [Related] [New Search]