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  • Title: [Characteristics of the label incorporation from 2-14C-glycine into the tissues of animals of differing ages].
    Author: Medovar BIa.
    Journal: Ukr Biokhim Zh; 1976; 48(5):572-6. PubMed ID: 1021910.
    Abstract:
    Peculiarities of 14C incorporation into proteins and lipids of the liver, kidneys, heart and muscles tissues as well as blood serum and protein-free filtrates of tissues were studied in young and old rats in different periods after glycin-2-14C administration. It is shown that incorporation of 14C into the tissue of young rats as well as its evacuation from the organism is more rapid. At the same time a change in dynamics of the precursors content in individual organs of animals of both age groups is of indirected character. A conclusion is drawn that acceleration of the radioactive label evacuation due to a more rapid exchange--ability of proteins in the young animals tissues might be one of the reasons of discrepancy between a higher level of radioactivity in the tissues of old rats and a total decrease in the intensity of metabolism during ontogenesis.
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