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  • Title: [Sterol content of rabbit erythrocyte membranes normally and in atherosclerosis].
    Author: Apukhovskaia LI, Vendt VP, Ivashkevich SP, Tsiomik VA.
    Journal: Ukr Biokhim Zh; 1976; 48(5):592-6. PubMed ID: 1021914.
    Abstract:
    The sterol composition of erythrocyte membranes was studied in norm and under experimental atherosclerosis. It is shown that in the normal animals the content of cholesterol in the membranes increases with age and practically reaches a relatively constant value by 5-6 months. In the experimental animals being on the atherogenic diet the amount of cholesterol in the membranes a month later is practically identical to the control. 5-6 months after the experiment the content of cholesterol in the membranes decreases as compared to the norm by 38 and 65%, respectively. On the basis of the IR- and UV-spectra one may suppose that with atherosclerosis in the C27-sterol fraction besides cholesterol, there appears sterol containing C=O-group, the mutual orientation of which relative to the neighbouring functional group is different as compared in the norm. The deepest changes in the qualitative composition of erythrocyte membranes is observed 5-6 months later when there appears some products of cholesterol or its precursor transformation. Such a modification of the sterol composition causes a change in the membrane permeability.
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