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  • Title: Binding of phenylbutazone to human serum albumin. Characterization and identification of binding sites.
    Author: Russeva V, Mihailova D.
    Journal: Arzneimittelforschung; 1999 Mar; 49(3):255-8. PubMed ID: 10219470.
    Abstract:
    The quantitative parameters characterizing the binding of phenylbutazone (CAS 50-33-9) to human serum albumin are determined using the circular dichroism titration method and a combined mathematical approach. The values of affinity constants obtained are in good agreement with those found in the literature. The characterization and identification of binding sites is also performed. A conclusion is derived that phenylbutazone can be used as a model compound for investigation of ligand-macromolecule interactions.
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