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  • Title: Effect of neutron-gamma radiation on dopamine and serotonin metabolism in the rat brain: a regional analysis.
    Author: Foulon O, Lalouette F, Lambert F, Martin S, Fatôme M, Martin C.
    Journal: J Neurosci Res; 1999 Mar 15; 55(6):770-5. PubMed ID: 10220117.
    Abstract:
    The concentrations of dopamine (DA) and its metabolites and the levels of 5-hydroxyindoleacetic acid (5-HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron-gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5-HIAA levels was noted.
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