These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The hippocampal opioidergic system: a comparative immunocytochemical study in four rodents.
    Author: Rácz B, Füzesi M, Halasy K.
    Journal: Neurobiology (Bp); 1998; 6(4):429-41. PubMed ID: 10220778.
    Abstract:
    The occurrence and distribution of four opioid peptides (methionine-enkephalin /met-enk/, leucine-enkephalin /leu-enk/, dynorphin-A /dyn-A/, dynorphin-B /dyn-B/) were studied and compared in the subregions and layers of the hippocampi of four rodent species (rat, mouse, hamster and guinea-pig) by means of pre-embedding immunocytochemistry in order to reveal species-specific morphological characteristics. Concerning the mossy fibre system, in the rat met-enk and dyn-A, in the mouse met-enk, in the the hamster dyn-A, in the guinea-pig dyn-B was found to be the dominating immunocytochemically detectable hippocampal opioid peptide. Outside the mossy fibre system, in other hippocampal areas met-enk-immunopositive varicose nerve fibres were most frequently detected in the rat and mouse, whereas dyn-B was the most abundant in the guinea-pig. In the hamster hippocampus all the four studied opioid peptides occurred at least in few varicose fibres. In the rat and mouse enkephalinergic boutons formed pericellular baskets around non-principal cells, whereas dynorphin-immunopositive boutons were visualized in similar arrangement around principal cells (both granule and pyramidal cells) in three of the studied species, except the rat. Among other species-specific differences, the presence of leu-enk-immunopositive perikarya in the golden hamster hippocampus, and a highly ordered leu-enk-immunoreactive fibre system exclusively detected in the CA1 area of the guinea-pig hippocampus are noteworthy. The results confirm the high degree of species-specific heterogeneity characterizing the distribution of the opioid peptides in the hippocampal formation.
    [Abstract] [Full Text] [Related] [New Search]