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  • Title: Influence of prostaglandins upon adenosine release and of adenosine upon prostaglandin release in the isolated rabbit heart.
    Author: Zehl U, Ritter C, Förster W.
    Journal: Acta Biol Med Ger; 1976; 35(11):K77-K82. PubMed ID: 1022127.
    Abstract:
    Prostaglandin (PG) E1 with its high effect of coronary dilation causes a distinct increase in the adenosine release from the isolated rabbit heart (Langendorff technique). Compared to this, an equal dose of PGF2alpha increases the release of adenosine only to a small extent. Conversely, application of adenosine results in a considerable release of PG-like substances from the rabbit heart in vitro. The present investigations support the hypothesis that, apart from adenosine, PG's too, are involved in coronary regulation as modulators.
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