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  • Title: Effects of ascorbic acid on selenium teratogenicity in cultured rat embryos.
    Author: Usami M, Tabata H, Ohno Y.
    Journal: Toxicol Lett; 1999 Mar 29; 105(2):123-8. PubMed ID: 10221274.
    Abstract:
    The effects of ascorbic acid, as an exogenous antioxidant, on selenium (Se) teratogenicity were examined using rat embryo culture. Rat embryos at day 9.5 of gestation were cultured for 48 h in the presence of sodium selenite at 10 and 20 microM or sodium selenate at 30 and 100 microM with or without the addition of 1 mM of L-ascorbic acid (AsA). Selenite or selenate alone increased the incidence of embryonic malformation. With AsA, the incidence of selenite-induced embryonic malformation was increased. On the contrary, the incidence of selenate-induced embryonic malformation was decreased with AsA. It was considered from these results that the redox states in the embryonic environment and of Se are critical in Se teratogenicity.
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