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  • Title: [The assessment of the effect of glucocorticosteroid and nonsteroidal anti-inflammatory preparations on the development of an erosive-ulcerative lesion of the gastrointestinal tract in patients with rheumatic diseases].
    Author: Karateev AE, Nasonova VA, Murav'ev IuV.
    Journal: Ter Arkh; 1999; 71(2):26-30. PubMed ID: 10222549.
    Abstract:
    AIM: A comparative evaluation of the frequency and severity of upper gastrointestinal mucosal lesions in patients taking nonsteroid anti-inflammatory drugs (NSAID) and glucocorticosteroids (GCS). MATERIALS AND METHODS: The trial entered 1086 rheumatic patients examined endoscopically. To compare the effects of their medicines, the patients were divided into 3 groups: 726 patients on NSAID alone (group 1); 238 patients on NSAID and GCS (group 2); 122 patients on GCS only (group 3). RESULTS: Gastropathies were diagnosed in 38.2, 32.4, 12.5% of group 1, 2 and 3 patients, respectively (the difference is significant). More serious diseases prevailed in group 1: multiple erosions and gastroduodenal ulcers. Group 2 and 3 patients had erosions only. CONCLUSION: GCS are safer for gastrointestinal mucosa than NSAID. Combination of NSAID with GCS does not increase the risk of gastropathy onset compared to NSAID alone.
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