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  • Title: Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.
    Author: Pandeya SN, Yogeeswari P, Sriram D, de Clercq E, Pannecouque C, Witvrouw M.
    Journal: Chemotherapy; 1999; 45(3):192-6. PubMed ID: 10224341.
    Abstract:
    The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT. In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.
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