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  • Title: Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens.
    Author: Olsovská J, Flieger M, Bachechi F, Messina A, Sinibaldi M.
    Journal: Chirality; 1999; 11(4):291-300. PubMed ID: 10224656.
    Abstract:
    The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
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