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  • Title: [The role of MHC class II genes in the etiopathogenesis of rheumatoid arthritis].
    Author: Lacki JK, Korczowska I, Mackiewicz SH.
    Journal: Przegl Lek; 1998; 55(10):524-7. PubMed ID: 10224866.
    Abstract:
    Rheumatoid arthritis (RA) is associated with HLA-DR4 and DR1 antigens. HLA-DRB1 gene sequences analysis demonstrated that only a limited set of alleles is positively associated with RA. Third hypervariable region sequences (70-74, 86) Q(R)R(K)RAA, G(V) are found in up to 95% of erosive RA. The presence of disease-associated allels may predict severe outcome of the disease. Therefore, their presence may allow us to start aggressive therapy in early stage of the disease.
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