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  • Title: Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation.
    Author: Kim CH, Kim JH, Hsu CY, Ahn YS.
    Journal: FEBS Lett; 1999 Apr 16; 449(1):28-32. PubMed ID: 10225421.
    Abstract:
    Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation. PDTC inhibited basal NF-kappaB activity of endothelial cells. PDTC, however, failed to inhibit basal NF-kappaB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc. When various preparations of metal ion-EDTA were tested with PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC. The dependence on zinc was also noted in PDTC inhibition of NF-kappaB stimulated by TNF alpha. These facts suggest that zinc is required for PDTC inhibition of NF-kappaB activation.
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