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  • Title: Predictive factors of response to leukocytapheresis therapy for ulcerative colitis.
    Author: Yajima T, Takaishi H, Kanai T, Iwao Y, Watanabe M, Ishii H, Hibi T.
    Journal: Ther Apher; 1998 May; 2(2):115-9. PubMed ID: 10225711.
    Abstract:
    Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.
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