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  • Title: Conformation of the Bax C-terminus regulates subcellular location and cell death.
    Author: Nechushtan A, Smith CL, Hsu YT, Youle RJ.
    Journal: EMBO J; 1999 May 04; 18(9):2330-41. PubMed ID: 10228148.
    Abstract:
    Bax, a pro-apoptotic member of the Bcl-2 family, translocates from the cytosol to the mitochondria during programmed cell death. We report here that both gain-of-function and loss-of-function mutations can be achieved by altering a single amino acid in the Bax hydrophobic C-terminus. The properly mutated C-terminus of Bax can target a non-relevant protein to the mitochondria, showing that specific conformations of this domain alone allow mitochondrial docking. These data along with N-terminus epitope exposure experiments suggest that the C- and the N-termini interact and that upon triggering of apoptosis, Bax changes conformation, exposing these two domains to insert into the mitochondria and regulate the cell death machinery.
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