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  • Title: [Cardiovascular effects of induction doses of the intravenous anesthetics, propofol, etomidate and thiopentone].
    Author: Djordjević B, Stojiljković MP, Loncar-Stojiljković D, Krivokapić D.
    Journal: Vojnosanit Pregl; 1999; 56(1):15-9. PubMed ID: 10230328.
    Abstract:
    After reviewing the results of published comparative studies by numerous authors we have noticed that propofol, among the other intravenous anesthetics, has the strongest cardiovascular effects. The aim of this study was to compare the cardiovascular effects of induction doses of propofol, etomidate and thiopentone. A total of 165 female patients were randomly divided into three groups, and each one received a different anesthetic agent: propofol 2.5 mg/kg (n = 58), etomidate 0.3 mg/kg (n = 54) or thiopentone 5 mg/kg (n = 53). the patients were scheduled for abortion (gravidity up to 12 weeks of gestation) in out-patient conditions. Indirect registration of systolic and diastolic blood pressure and palpatory registration of radial pulse was performed: on admittance, immediately before the induction of anaesthesia and 2, 5 and 10 min thereafter. Following the administration of induction dose of propofol, a significantly greater decrease of systolic and diastolic blood pressure was observed then after the administration of etomidate or thiopentone. Slowing down of radial pulse was also more marked in propofol, then in etomidate or thiopentone group. The results of our study had shown that the induction dose of propofol had stronger effects on cardiovascular system, compared to the induction doses of etomidate or thiopentone.
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