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  • Title: Content and structure of ceramide and sphingomyelin and sphingomyelinase activity in mouse hepatoma-22.
    Author: Rylova SN, Somova OG, Zubova ES, Dudnik LB, Kogtev LS, Kozlov AM, Alesenko AV, Dyatlovitskaya EV.
    Journal: Biochemistry (Mosc); 1999 Apr; 64(4):437-41. PubMed ID: 10231598.
    Abstract:
    The relative content of phosphatidylcholine is lower and that of sphingomyelin is higher in transplantable fast growing mouse hepatoma-22, thus decreasing their ratio approximately 2.5-fold versus normal liver. The ceramide content and the neutral sphingomyelinase activity is markedly higher (3- and 6.5-fold, respectively), whereas the acid sphingomyelinase activity is 4-fold lower in hepatoma-22 versus normal liver. The content of saturated fatty acids in ceramide and sphingomyelin of hepatoma-22 is higher than in normal liver. All sphingolipids of hepatoma-22 contain a considerable amount (25-37%) of sphinganine (dihydrosphingosine) along with sphingenine (sphingosine), whereas sphingolipids of normal liver contain predominantly sphingenine (over 95%). These results indicate that the activity of enzymes involved in sphingolipid biosynthesis and catabolism is disturbed in the transplantable mouse hepatoma-22 compared to normal liver.
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