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  • Title: [Effect of epiphysectomy on the circadian rhythm of the glucocorticoid, androgen, estrogen and gestagen functions of the endocrine organs].
    Author: Golikov PP, Bobkova AS.
    Journal: Probl Endokrinol (Mosk); 1976; 22(5):77-81. PubMed ID: 1023188.
    Abstract:
    Investigations were carried out on intact, pseudoectomized and epiphysectomized Wistar rats (male and female) with the following illumination regimen: light--10 hours, darkness--14 hours. By the method of competitive protein binding and by fluorimetry a determination was made of the blood content of corticosterone, estrogens, androgens and gestagens. The peripheral blood content of the hormones under study in the intact animals corresponded to literature data. In comparison with the intact animals epiphysectomy changed the circadian rhythm of the blood corticosterone (11-OCS) level. In comparison with the pseudoepiphysectomized animals, in the epiphysectomized animals the progesterone content fell significantly at 6 a.m., at noon, and at 6 p.m. In comparison with the intact group, under the effect of epiphysectomy estrogen and androgen content increased at almost all the observation hours.
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