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  • Title: Splenic lymphoma with villous lymphocytes presenting as leucocytoclastic vasculitis.
    Author: Farrell AM, Stern SC, El-Ghariani K, Frankel A, Woodrow D, Muller B, Cream JJ.
    Journal: Clin Exp Dermatol; 1999 Jan; 24(1):19-22. PubMed ID: 10233643.
    Abstract:
    We describe a 69-year-old woman who presented with purpura on the legs. Examination of a blood film revealed a homogenous population of abnormal lymphoid cells with villous projections. The immunophenotype was consistent with a diagnosis of splenic lymphoma with villous lymphocytes (SLVL). A type II (IgM-IgG) cryoglobulin was detected in the serum. Renal biopsy demonstrated a membranoproliferative type I glomerulonephritis with intraluminal IgG and IgM deposits, and a skin biopsy showed a leucocytoclastic vasculitis with outlining of the vessels by IgG and IgM. Vasculitis has been reported in association with a number of haematological malignancies, most frequently with hairy cell leukaemia. To our knowledge this is the first report of SLVL presenting with cryoglobulinaemic vasculitis.
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