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  • Title: [The role of mitochondria in apoptosis in U937 and Molt-4 cells: difference in order of mitochondrial membrane potential (delta psi m) reduction and interleukin-1 beta-converting enzyme (ICE) on signal transduction pathway in each cell type].
    Author: Kawaguchi M, Nakamura A, Tsurusawa M.
    Journal: Gan To Kagaku Ryoho; 1999 Apr; 26(5):679-85. PubMed ID: 10234300.
    Abstract:
    Time-course-analysis of two apoptotic events of DNA fragmentation and delta psi m reduction revealed that delta psi m reduction preceded DNA fragmentation in U937 and Molt-4 cells treated with etoposide (ETP). DNA fragmentation and delta psi m reduction were inhibited by N-acetylcysteine (NAC) in both cell lines treated with ETP. These findings suggest that DNA fragmentation was inhibited through maintenance of delta psi m. Z-Asp-CH2-DCB, interleukin-1 beta-converting enzyme (ICE) specific inhibitor, inhibited ETP-induced DNA fragmentation and delta psi m reduction in U937 cells. This suggests that activation of ICE is an earlier event than delta psi m reduction. On the other hand, in Molt-4 cells, Z-Asp-CH2-DCB inhibited ETP-induced DNA fragmentation but not delta psi m reduction, suggesting that delta psi m reduction occurs earlier than activation of ICE.
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