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  • Title: Lack of an allelic association between polymorphisms of the dopamine D2 receptor gene and alcohol dependence in the German population.
    Author: Sander T, Ladehoff M, Samochowiec J, Finckh U, Rommelspacher H, Schmidt LG.
    Journal: Alcohol Clin Exp Res; 1999 Apr; 23(4):578-81. PubMed ID: 10235291.
    Abstract:
    Our study examined recent claims of an association of the TaqI A1 allele and the functional -141C Ins allele of the dopamine D2 receptor (DRD2) gene with alcohol dependence. Genotypes of the TaqI A and -141C insertion/deletion polymorphisms were assessed in 196 German nonalcoholic controls and 310 German alcohol-dependent subjects, including two more homogeneous subgroups selected by either a history of parental alcoholism (n = 108) or by a history of severe physiological alcohol withdrawal symptoms (n = 99). We found no association between any of the biallelic variants or the A1/Ins haplotype and alcohol dependence (p > 0.05). Our present association results failed to replicate evidence that either the TaqI A1 allele or the functional Ins allele or the A1/Ins haplotype of the DRD2 gene confers vulnerability to alcohol dependence in the German population.
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