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  • Title: [Morphological manifestations of secretory activity of the neutrophils in inflammation].
    Author: Pigarevskiĭ VE, Tolybekov AS, Tuchkov BS, Blinkova EN.
    Journal: Arkh Patol; 1976; 38(5):55-60. PubMed ID: 1023852.
    Abstract:
    Neutropholic leukocytes of aseptic peritoneal exudate of rabbits differed from neutrophilic leukocytes of the blood in greater variability in the content of cationic proteins. Some lysosomes ceased to be stained on cationic proteins, which produced a false impression of degranulation of leukocytes. Ultramicroscopically, there was observed a "clearing" of the lysosomes content and its outflow into cytoplasm. Lysosomes acquired the shape of spherical "holed" bodies and were transformed into clear vacuoles with remnants of the electron-dense material. The rupture of lysosome membranes led to an "explosive" type of liberation of the lysosome content into the cytoplasm. Partly degranulated leukocytes remained vital and activity moved about in a homologous serum. Following contacts with histone F1 leukocytes lost cationic proteins. The liberation of cationic proteins from leukocytic took place without destruction of leukocytes and lysosomes themselves.
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