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  • Title: [Dynamics of the mass of the right ventricle of the heart and concentration of RNA in it during the process of "reverse" development of hypertrophy].
    Author: Kolokol'chikova EG, Korol'kov VI.
    Journal: Biull Eksp Biol Med; 1976 Dec; 82(12):1421-2. PubMed ID: 1023964.
    Abstract:
    Experiments were conducted on male rats, 250-300 g in weight. Adaptation to high altitude hypoxia was created by placing the animals daily for 5 hours, into an altitude chamber, at an "altitude" of 6000 m. The degree of hypertrophy of the right ventricle and its RNA content was studied after 20 days of adaptation, as well as 2, 10, 20 and 40 days after cessation of hypoxia. Twenty days after the beginning of adaptation the muscle mass of the right ventricle the RNA concentration and amount in it was found to increase considerably. After cessation of hypoxia half of the acquired increase in the ventricle muscle mass was lost in 10 days, and half of the acquired increase in the RNA--as soon as in 2 days. Forty days after cessation of hypoxia the right ventricle mass and its RNA content in the adapted animals did not differ from the same indices in control rats.
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