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  • Title: [Bone marrow colony-forming capacity in mice subjected to burn trauma].
    Author: Zherbin EA, Semina OV, Neprina GS, Poverennyĭ AM.
    Journal: Biull Eksp Biol Med; 1976 Dec; 82(12):1424-6. PubMed ID: 1023966.
    Abstract:
    A method of exogenous splenic colonies was applied to the study of the dynamics of the content of the colony-forming units (CFU) in the bone marrow of CBA mice to which thermal burn of the III degree of 15% of the body surface was inflicted. On the 4th and 16th days after the burn the CFU content in the bone marrow of mice decreased 1.7-2.1 times. The thymus cells of the intact mice administered simultaneously with the bone marrow of the burned mice increased, the amount of the splenic exogenous colonies formed in the recipients. The data obtained permitted to make a suggestion that not only the CFU count diminished in the bone marrow in the burned animals, but also the thymus-dependent cells necessary for normal colony formation.
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