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  • Title: Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.
    Author: Hoffstein S, Soberman R, Goldstein I, Weissmann G.
    Journal: J Cell Biol; 1976 Mar; 68(3):781-7. PubMed ID: 1025156.
    Abstract:
    Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.
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