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  • Title: [Study of carbohydrate metabolism in rats after administration of myocardium-damaging doses of adrenaline].
    Author: Vereshchakova EP.
    Journal: Kardiologiia; 1976 Apr; 16(4):117-22. PubMed ID: 1025323.
    Abstract:
    The investigation included a study of the content of glycogen, of the activity of the enzymes of its decay (phosphorylase and hydrolytic enzymes), of the content of lactic acid, and glucose in rats following the administration of myocardium damaging doses of adrenalin, as well as in animals who had died after the administration of adrenalin or were agonizing. The analysis of the carbohydrate metabolism parameters in animals who had died due to the adrenalin administration, or who had been sacrificed in an agonizing state (sharp fall of the glycogen content in the heart, increased activity of hydrolytic enzymes in the heart during the agonizing phase) indicated that the temporary elevation of the glycogen content in the heart after the administration of 300microng/100g of adrenalin was a compensatory reaction of the body. It is suggested that a certain relationship exists between the markedness of this compensatory reaction, i.e. the glycogen level in the heart muscle, and the severity of necrotic lesions.
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