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  • Title: N-acetyl-beta-glucosaminidase of peripheral blood lymphocytes in patients with cancer of the larynx.
    Author: Gierek T, Astaldi G, Lisiewicz J, Pilch J.
    Journal: Tumori; 1976; 62(6):645-50. PubMed ID: 1025803.
    Abstract:
    In 20 men, age 35 to 55 years, with cancer of the larynx of N-acetyl-beta-glucosaminidase in peripheral blood lymphocytes was determined cytochemically according to Hayashi's method. Numbers of enzyme-positive cells were counted with regard to the type of cytochemical reaction (granular, granular-diffuse, or diffuse), and to the number of enzyme-positive lysosomal granules within a single cell. In comparison to 20 healthy men, age 20 to 30 years, the following changes were noted in the patients: 1) the decrease of the total count of enzyme-negative lymphocytes; 2) the decrease of the total count of lymphocytes with granular type of reaction; 3) the increase of the counts of lymphocytes with granular-diffuse and diffuse type of reaction. The authors suggest that these changes could be related to the immune reaction of specific tumor antigens.
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