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  • Title: [Effect of adaptation to altitude hypoxia in early ontogeny on the indices of higher nervous activity].
    Author: Meerson FZ, Radzievskiĭ SA.
    Journal: Biull Eksp Biol Med; 1976 Aug; 82(8):902-3. PubMed ID: 1026280.
    Abstract:
    Newborn male and female Wistar rats were adapted to hypoxia in a pressure chamber. Adaptation was started from the "altitude" of 1000 m, 1 hour daily, and then the time and the intensity of hypoxic actions were gradually increased: beginning from the 17th day the animals were subjected to adaptation to the "altitude" of 5000 m, for 5 hours, 5 days a week. The defence conditioned reflex of active avoidance was provoked in the animals after 2-month adaptation. A tendency to a more rapid elaboration of the reflex and a markedly enhanced degree of its retention in comparison with control was revealed in the adapted males. No significant changes in the elaboration and rentention of the reflex were found in the female animals adapted to hypoxia under analogous conditions.
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