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  • Title: [Characteristics of the antivitamin effect of pyriditol, a disulfide pyridoxine derivative, on animal body].
    Author: Moiseenok AG, Bobrova NP, Avakumov VM, Kovler MA.
    Journal: Farmakol Toksikol; 1976; 39(3):308-11. PubMed ID: 1026514.
    Abstract:
    Intraperitoneal administration of disulphide pyridoxine (pyriditol) to albino mice in a dose of 300 mg/kg brings down the GABA level and the GABA-transaminase activity in the brain, the glutamic acid content and the glutamate-decarboxylase activity remaining unchanged. In the liver and, especially, in the kidneys of test animals the activity of aspartate-and alanine-aminotransferase goes down. The diurnal urinary output of the animals shows a decreased passage of 4-pyridoxic acid. These results are interpreted to be consequent upon the antivitamin action of pyriditol with respect to pyridoxine.
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