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  • Title: Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks.
    Author: Dvilansky A, Rishpon S, Nathan I, Zolotow Z, Korczyn AD.
    Journal: Pain; 1976 Sep; 2(3):315-318. PubMed ID: 1026904.
    Abstract:
    Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor(s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.
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