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  • Title: Hepatic vitamin A fat-storage cells and the metabolism of chylomicron cholesterol.
    Author: Redgrave TG, Vakakis N.
    Journal: Aust J Exp Biol Med Sci; 1976 Dec; 54(6):519-25. PubMed ID: 1027409.
    Abstract:
    These experiments were designed to test the hypothesis that the vitamin A fat-storage cell removes chylomicron remnant cholesterol from hepatic portal venous blood; A modified Ficoll density gradient ultracentrifugation procedure was used to isolate from rat liver cellular fractions that were enriched in vitamin A. In rats fed a normal diet and in rats fed excess vitamin A isolated hepatocytes were fractionated 15 min after the intravenous injection of chylomicrons labelled in vivo with radioactive cholesterol. The results showed that cholesterol radioactivity was not concentrated in the vitamin A enriched cellular fractions, so it was concluded that the vitamin A fat-storage cell is not implicated in clearance of chylomicron remnants by the liver.
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