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  • Title: [Characteristics of liver circulation and the outflow of bile and lymph in acute carbon tetrachloride poisoning].
    Author: Koval'skaia KS, Gorin AS.
    Journal: Farmakol Toksikol; 1976; 39(4):458-62. PubMed ID: 1027571.
    Abstract:
    In acute tests set up on 13 dogs the pressure and blood flow in the portal vein and hepatic artery, the pressure in the inferior vena cava along with lymph- and bile currents were registered following intraportal introduction of CCI4. Subject to determination were also the resistance of venous and arterial hepatic vessels and of the splachnic zone, as well as the summary blood flow. The rising pressure and diminished blood flow in the portal vein were found to be the result of the growing resistance of venous vessels in the liver. Falling pressure and reduced blood flow in the hepatic artery bore witness to the general toxic effect of CCl4 on the animal organism. Increased portal pressure and disturbed permeability of biological membranes was attended by a greater lymph outflow. The inhibition of bile secretion came as a result of hypoxic and toxic damage of the liver.
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