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  • Title: [Effects of catecholaminergic substances on the circular reaction caused by stimulation of the caudate nucleus].
    Author: Dutov AA.
    Journal: Farmakol Toksikol; 1976; 39(5):537-40. PubMed ID: 1028579.
    Abstract:
    The influence of stimulators (L-DOPA and apomorphine) and of inhibitors (chlorpromazine and haloperidol) of the dopaminergic systems on the circular reaction arising during high-frequency (30 puls/sec) stimulation of the caudate nucleus was studied in chronic experiments with freely moving cats carrying preliminarily implanted electrodes. L-DOPA and apomorphine inhibited, while chlorpromazine, on the contrary, facilitated the development of a contralateral circular reaction. L-DOPA and chlorpromazine modified in a more pronounced fashion the circular reaction than did apomorphine and haloperidol. In the mechanisms of the circular reaction, apart from the dopaminergic component, the participation of noradrenergic systems is suggested.
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