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  • Title: [Effect of apressine and euphylline on the bioelectric activity and electrolyte balance of the vascular wall].
    Author: Gul'kin AV, Voronkov IF.
    Journal: Farmakol Toksikol; 1976; 39(5):582-6. PubMed ID: 1028586.
    Abstract:
    In tests staged on cats the effect of apressin and euphylline on the biopotential and electrolytes metabolism was studied. Apressin was found to raise the negative electricity of the biopotential and the potassium level in the vascular tissue, an increase of the dose producing not any further reduction, but rather a higher concentration of calcium in the arterial vessels. Euphyliine causes no changes in the biopotential, but then raises the potassium content in the vascular wall. An accertion of the euphylline dose blocks the egress of calcium from the muscular tissue of the arteries. It is suggested that the relaxing action of the introduced substances maycome about owing to stimulation of the processes infolving binding of calcium in the smooth muscle cells, while changes in the transparietal potential difference are conditioned mainly by counter-gradient transport of potassium.
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