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  • Title: [Role of intermediate products of prothrombin proteolysis by thrombin in the stimulation of the anticoagulation system of blood].
    Author: Kudriashov BA, Strukova SM, Orlova AS, Liapina LA.
    Journal: Biull Eksp Biol Med; 1976 Oct; 82(10):1172-4. PubMed ID: 1029494.
    Abstract:
    Two components - the intermediate product 1 (P-1) converting under certain conditions into thrombin, and product 2 (P-2) which possesses no such properties were isolated from the products of prothrombin proteolysis by thrombin. The intravenous injection of the P-1 to rats lengthened the blood coagulation time and plasma recalcification. The sum total fibrinolytic activity proved to increase and the fibrinogen concentration - to decrease. A sharp 5-fold rise of the nonfermentative fibrinolysis was observed. It seems that this effect of the anticoagulating and fibrinolytic potential mobilization was stimulated by the response of the second anticoagulating blood system.
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