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  • Title: Interferon synthesis in mouse peritoneal cells damaged by X-irradiation.
    Author: Szolgay E, Tálas M.
    Journal: Intervirology; 1976; 7(6):338-45. PubMed ID: 1030693.
    Abstract:
    NDV-induced interferon of peritoneal cells of irradiated (X-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80--90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.
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