These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heptanol exerts epileptiform effects in identified neurons of the buccal ganglia of Helix pomatia.
    Author: Tarner IH, Altrup U, Speckmann EJ.
    Journal: Neurosci Lett; 1999 Apr 02; 264(1-3):73-6. PubMed ID: 10320017.
    Abstract:
    1-Heptanol (0.2-5.0 mM) known to block electrical contacts was tested under epileptic and non-epileptic conditions in the buccal ganglia of Helix pomatia. Synchronicity of epileptiform activity was not affected. In concentrations below 1 mM, heptanol accelerated epileptiform activity induced by pentylenetetrazol. In concentrations above 1 mM, it evoked epileptiform activity without admixture of an epileptogenic drug. Coupling coefficient was increased and decreased in low and high concentration ranges of heptanol, respectively. The measured decrease of coupling is interpreted as a result of the activation of 'epileptiform' membrane conductances accompanied by decreased length constants of neuronal fibers.
    [Abstract] [Full Text] [Related] [New Search]