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  • Title: [Preparation of monoclonal antibodies against hepatitis E and its application].
    Author: Jiang L, Su C, Shen X.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 1998 May; 32(3):174-6. PubMed ID: 10322795.
    Abstract:
    OBJECTIVE: To study the particle of hepatitis E virus (HEV) and its significance in specific diagnosis for hepatitis E (HE). METHODS: Four strains of monoclonal antibodies (McAb) against HEV, 5B12, 5F1, 5B9 and 4G10, were prepared with HEV antigen (used as immunogen) expressed by genetic engineering and detected by indirect enzyme-linked immunosorbent assay (ELISA) with purified synthetic polypeptide antigen. RESULTS: The monoclonal anti-HEV prefared could produce inhibitory reaction with anti-HEV positive serum and combined specifically with HEV particle forming virus-antibody complex seen clearly under electron microscope. CONCLUSION: McAb against HEV so prepared with high specificity can be used to detect and identify HEV.
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