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  • Title: [Studies on infection of Helicobacter pylori and their subtypes cagA+ and hspA+ in population living in the areas with high and low incidence of gastric cancer].
    Author: Zhang L, Ma J, Pan K.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 1998 Mar; 32(2):67-9. PubMed ID: 10322798.
    Abstract:
    OBJECTIVE: To explore the difference in infection of Helicobacter pylori (Hp) and their subtypes cagA+ and hspA+ in the residents living in the areas with high and low incidence of gastric cancer. METHODS: Immunoglobulin G and A antibodies against Hp and immunoglobulin G antibodies against cagA+ and hspA+ were detected for the residents in Linqu and Cangshan Counties of Shandong Province with enzyme-linked immunosorbent assay (ELISA). RESULTS: Rate of infection with Hp in the residents in Linqu County, an area with high incidence of gastric cancer, was 73.8 percent, significantly higher than that in Cangshan County (59.9%), an area with low incidence. Rates of infection with Hp cagA+ and hspA+ in the residents in Linqu County were 50.9 and 17.0 percent, respectively, also significantly higher than those in Cangshan County (34.0% and 13.2%, respectively). Sensitivities and specificities of the methods for detecting antibodies against Hp, cagA+ and hspA+ were 92.3, 63.2 and 21.9 percent and 71.0, 80.6 and 95.2 percent, respectively, evaluated with 13C-urea breath teat (13C-UBT). Rate of infection with Hp, especially with Hp cagA+, correlated significantly with the high incidence of gastric cancer. CONCLUSION: The methods for detecting antibodies against Hp and cagA+ subtype are more sensitive and can be used as better indicators in epidemiological studies on gastric cancer.
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