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  • Title: [Follow-up on hepatitis B immunized neonates born to HBsAg positive mothers].
    Author: Zhang X, Xing Y, Shen L.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 1998 Mar; 32(2):97-9. PubMed ID: 10322808.
    Abstract:
    OBJECTIVE: To determine the immune persistence in neonates born to hepatitis B surface antigen (HBsAg) positive mothers with different schedules for HB immunization. METHODS: Two hundred and three neonates born to HBsAg positive mothers were immunized at birth with HB vaccine in different schedules and doses, and followed-up for six years continuously for antibodies against HBs (anti-HBs) and carriage status of HBsAg. RESULTS: Prevalence of anti-HBs in the neonates kept in more than 90% during the six years since immunization, with a peak at the ages of seven to twelve months and decreasing by 48.82% at the ages of one to two years. Their anti-HBs kept relative stable during two to six years of age. Eight children converted to anti-HBs negative for three to five years still kept uninfected. Fourteen children converted to anti-HBs negative reconverted positive again one to two years later. No single chronic carrier with HBsAg was found in them. CONCLUSION: A booster dose of HB vaccine seems unnecessary for children in six to ten years after primary immunization.
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